Target Markets & Applications 2018-03-22T21:27:37+00:00

It is estimated that there are over 500,000 skin tightening procedures performed in the U.S. annually and the number is projected to grow rapidly with the introduction of newer more effective technologies (ASAPS 2016).

Target Markets

One of the most visible signs of aging is the development of skin laxity. This lifelong process may become evident as early as the third or fourth decade of life and progressively worsens with the passage of time. Histological research has shown that dependent stretching or age-related skin laxity is due in part to progressive skin atrophy associated with a reduction of skin tensile strength. When combined with the downward force of gravity, age related dermal atrophy results in the expansion of the skin envelope. The most affected areas are the neck, upper arms, inner thighs, breasts, lower abdomen and knee regions.

The frequency and negative societal impact of these aesthetic conditions has prompted the development of surgical procedures such as facelifts, mastopexies (breasts), abdominoplasties (abdomen) and brachioplasties (upper arms). While these procedures have been widely used, the inherent adverse effects of these surgical procedures are post-operative pain, scarring and the risk of surgical complications. With a number of these procedures, plastic surgeons have developed techniques to “hide” the extensive scarring from the procedure, but this is difficult in skin areas such as the upper arms, neck, inner thighs and areas above the knee.

Potential Clinical Applications

Loose Skin

Historically loose skin has been treated with electromagnetic medical devices that create a reverse thermal gradient. However, these devices have had variable success to reduce skin laxity without surgery.

We believe that the Company’s RFR platform will significantly improve aesthetic outcomes for focal aesthetic contouring by removing excess skin and fat without the appearance of visible scarring. Targeted areas of the body that are poorly served by existing technologies and surgery will be the initial focus for the Company. Rotational Fractional Resection should enhance aesthetic outcomes by reducing the complexity, repeated treatments and recovery period of currently available procedures.

Finally, because of the safety features and potential for reproducible results, RFR should expand the number of medical aesthetic physicians that can successfully treat these patients.

Regrettable Tattoos

According to a recent study, 30% of all American adults now have tattoos; and 29% of those tattooed now regret getting tattoos (Harris Poll 2015). Lasers are the primary technology used today for the removal of tattoos. However, another recent study (N=397) reported that only 47% of those undergoing laser treatment with 10 treatment sessions reported a successful outcome (Consumer Reports).

RFR tattoo removal will probably be achieved with 4 to 5 successive treatments conducted about one month apart. This approach to tattoo removal could be faster and more complete than any other treatment option.

Market analysts predict that with effective technologies, tattoo removal could be one of the largest markets in aesthetic dermatology in the future. We believe that the ease of use, fewer treatment sessions, lower cost and enhanced efficacy for dye removal will drive the use of more effective technologies for tattoo removal.

Unsightly Scars

There are numerous causes for the formation of scars. Scars are caused by either trauma or a surgical procedure which results in the formation of scar tissue. Scars are often irregularly formed and are often further demarcated by a pigmentary difference from the adjacent normal skin. Scar revision is currently conducted utilizing cryotherapy, pressure therapy, surgery or lasers. A variety of different lasers are used to smooth, flatten or remove the abnormal color of the scar; and there were over 170,000 scar revision procedures performed in the U.S. in 2014 (Lim et al, PRS 2014 Feb 133(2): 398-405).

Excessive scarring can also occur from the excision of a scar lesion. Many of these scars are unsightly due to irregular pigmentation from a shaved lesion excision. Fractional scar revision should reduce the visual impact of these scars by reducing the surface area of these unsightly deformities. The potential also exists to shorten incisions required to elliptically excise lesions of the skin. With this application, each end of the excision will be fractionally resected instead of being lengthened by elliptical excision to avoid a “dog ear” skin redundancy.

The Company expects that the single scalpet and multi-scalpet array platforms will provide medical aesthetic physicians with an effective and less invasive alternative that can be performed in the office setting.

Fat Defects

Focal lipectomy will be a new clinical option afforded by the tiny rotating lipectomy cannula that is included as a unique consumable component of the RFR system. In the past, localized deposits of excess fat (focal lipodystrophy) has been treated either by traditional liposuction or with energy-based devices with modest clinical outcomes requiring several treatments.

Most medical aesthetic physicians do not choose to conduct traditional liposuction, even though many patients would prefer to have their focal fat deposits  directly removed so that multiple treatments are not nessessary. RFR focal lipectomy incorporates targeted fat extraction as a complementary benefit where both fat accumulation and skin laxity are present.